Van de Ven Double Ends Everton's Run at New Stadium
The Dutch defender became the initial defender to net twice in a English top-flight match for Tottenham since the Belgian defender in March 2013.
Match summary
The Spurs defender nods home twice in opening period
The home side's Jake O'Brien has goal disallowed after VAR review
Senegalese midfielder nets final goal in dying moments
The defeat is Everton's first at Hill Dickinson Stadium
Micky van de Ven scored on two occasions as Spurs prolonged their unbeaten run in away games in the Premier League and handed Everton their first defeat at their new home.
The Toffees were undefeated in their five previous fixtures at their new ground at the dockside location, having left their historic home behind after more than a century at the end of the previous campaign.
But Tottenham's leader the Dutchman struck twice from set-pieces in the opening 45 minutes to place their strong form at jeopardy, and they were failed to mount a comeback before the midfielder - assisted by ex-Everton forward Richarlison - nodded in a final goal to put the game to bed.
Jake O'Brien thought he had equalized the scores a short while after Van de Ven's opener, directing a powerful header past Guglielmo Vicario from an Everton corner.
Beto, meanwhile, missed a handful of opportunities, while the Italian goalkeeper made a series of fine saves to ensure Tottenham went five away games unbeaten in the English top flight.
But the video assistant referee intervened, advising Craig Pawson to review the score on the screen and the referee decided that Jack Grealish and the attacker were in offside positions and had interfered with the Tottenham goalkeeper.
This victory elevates the manager's team up to third in the division, five points off north London rivals and leaders the Gunners.
Everton remain in 14th position and are six points ahead of the relegation zone.
Spurs breakdown: Van de Ven fulfils role at each end of the field
Following a drab weekday performance in the Champions League against Monaco, where they managed a mere two shots on target, the manager opted for Randal Kolo Muani up front instead of former Toffees player Richarlison.
The new arrival was unable to influence the game before being replaced for the substitute after an hour on the pitch, but it turns out he wasn't needed in the end.
Defender Van de Ven transformed into an offensive threat to be reckoned with.
Tottenham's opening strike came from a cleverly executed set-piece play, with Rodrigo Bentancur directing the ball toward the six-yard box for an free Van de Ven to score.
And Ven de Ven - stepping up as captain in Cristian Romero's unavailability - notched his second in added time as he rose above Jordan Pickford to nod in.
The Dutchman was equally impressive in defensive duties, combining well with Kevin Danso as the duo dealt superbly with the numerous deliveries thrown their way by the opposition.
Toffees breakdown: Toffees missing finishing touch
Everton's new home had been a happy hunting ground, but it appears the novelty may have worn off slightly and supporters headed to the gates after the midfielder's final goal for Tottenham.
The break in Everton's winning streak at home won't be a major concern for the manager, but their striker situation are.
Beto and Thierno Barry - the Everton's pair of recognised strikers - had netted just one league goal combined before Sunday's outing.
And they were failed to add to that poor tally on a wet and gloomy evening on in Liverpool.
The striker's form was epitomized when he opted to overhead kick a clear chance from near the goal, even with having room and time to readjust for a more conventional shot that would have challenged the keeper.
The substitute, too, was unable to influence the game after replacing the starter in the second half.
It wasn't for a lack of opportunity. The majority of Everton's attacks came through Grealish and the forward, who tirelessly whipped threatening balls into the Spurs box.
Upcoming fixtures for these two sides?
Everton: Moyes' men head to the Stadium of Light in the Premier League on Monday, 3 November at 20:00 GMT.
Tottenham: The London club go to St James' Park on Wednesday, 29 October for their next round Carabao Cup match against the Magpies.